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The movie tells the story of two friends, the taciturn Tommaso and the exuberant Giuliano – the former lives in Canada, while the latter is in Rome. When Giuliano, who is seriously ill, makes an irreversible decision, Tommaso overcomes his fear of flying and visits him in Rome to spend their last four days of friendship together. The two are not alone: the third star is the Giuliano’s dog, called Pato.

When a nun in a remote convent claims immaculate conception, the Vatican sends a team of priests to investigate, concerned about an ancient prophecy that a woman will give birth to twin boys: one the Messiah, the other the Anti-Christ.